Annual Meeting of the Society for Free Radical Research (Australasia)
Griffith University, Gold Coast, Australia
December 5-7, 2016

Final programme

Monday, December 5, 2016

Time

Chair

Presenter

Title

8.00

Registration opens

8.50-9.00

Opening of Conference

9.00-10.00

Keynote Talk
Jiri Neuzil

R. Stocker
Sydney

KT1 Indoleamine 2,3-dioxygenase in vascular health and disease

10.00-10.30

Coffee Break

10.30-12.05

L. Dong
M. Hampton

Session 1: Neoplastic Diseases I

10.30

 

S. Pervaiz Singapore

LT1 Serine 70 phosphorylated Bcl-2 inhibits DNA damage by regulating mitochondrial ROS

10.50

 

J. Neuzil
Gold Coast

LT2 Horizontal transfer of mitochodnria and metabollic remodelling are prerequisites for tumour formation

11.10

 

J. Truksa
Prague

LT3 Oxidative stress and tumour-initiating cells

11.30

 

M. Vissers Christchurch

LT4 Exploring the relationships between ascorbate, hypoxia and cancer: Oxidant, antioxidant or enzyme co-factor?

11.50

 

S. Boukalova
Prague

ST1 Mitochondrial targeting of metformin enhances its anti-tumour effects in pancreatic cancer

12.05-13.00

Lunch Break

13.00-14.30

S. Boukalova
A. Bulmer

Session 2: Young Investigators

13.00

 

W. Chen
Sydney

YI1 The effect of deletion of biliverdin reductase on oxidative stress in mouse models

13.10

 

Z. Kovacevic
Sydney

YI2 Novel redox-active thiosemicarbazones for the treatment of aggressive breast cancer: A multi-faceted effect involving the metastasis suppressor NDRG1

13.20

 

P. Raninga
Brisbane

YI3 Targeting the redox protein, thioredoxin reductase 1 for treating drug-resistant multiple myeloma

13.30

 

A. Denny
Christchurch

YI4 Post-translational modification of CaMKII underlies the patho-physiology of facioscapulohumeral muscular dystrophy

13.40

 

K. Rohlenova
Prague

YI5 Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer

13.50

 

L. Hall
Sydney

YI6 Oral pre-treatment of Sprague-Dawley rats with thiocyanate protects against myocardial ischaemia-reperfusion injury

14.00

 

C. Stanley Sydney

YI7 An amino acid-derived hydroperoxide as a novel signalling molecule in the regulation of vascular tone

14.10

 

G. Fong
Sydney

YI8 Mechanism of neuroprotection by capsaicin in a model of Parkinson's disease

14.20

 

T. Hoskin
Christchurch

YI9 Calprotectin oxidation occurs at inflammatory sites and impacts on its biological function

14.30-15.00

Coffee Break

15.00-16.45

J. de Haan
S. Dukie

Session 3: Neoplastic Diseases II

15.00

 

A. Viale
Houston

PT1 Metabolic targeting of chemoresistance perturbs clonal complexity in pancreatic cancer

15.30

 

D. Richardson
Sydney

LT5 Fire and brimstone: Turning the gun on cancer

15.50

 

L. Dong
Gold Coast

LT6 Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

16.10

 

S. Hubackova
Prague

LT7 Elimination of senescent cells by mitochondria-targeted compounds: Re-purposing of anti-cancer agents

16.30

 

V. Gopalan
Southport

ST2 New targets in the molecular pathways of colorectal cancers and its clinicopathological implications

16.45-17.45

P. Witting

Lifetime Achievement Award Presentation

16.45

 

K. Croft
Perth

Dietary polyphenols: Antioxidants or not?

17.45-20.00

Poster Viewing + Welcome Mixer

 


 

 

Tuesday, December 6, 2016

Time

Chair

Presenter

Title

8.30-9.55

K. Tonissen
J. Headrick

Session 4: Cardiovascular and Metabolic Diseases I

8.30

 

G. Drummond
Melbourne

PT2 Inhibition of inflammasome signalling as a mechanism for the anti-inflammatory actions of nitric oxide

9.00

 

L. Vitek
Prague

LT8 Anti-atherogenic effects of bilirubin: From bedside to bench

9.20

 

S. Thomas
Sydney

LT9 Redox control of the key immune regulatory enzyme indole-amine 2,3-dioxygenase 1 by Nox2-derived ROS in human monocytes

9.40

 

B. Rayner
Sydney

ST3 The unfolded protein response initiates the astrocyte inflammatory response following exposure to hypothiocyanous acid

9.55-10.25

Coffee Break

10.25-12.00

R. Ritchie
L. Vitek

Session 5: Cardiovascular and Metabolic Diseases II

10.25

 

K.-H. Wagner
Vienna

LT10 Age and the effect of exercise, nutrition and cognitive training

on oxidative stress

10.45

 

P. Witting
Sydney

LT11 Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin

11.05

 

J. de Haan
Melbourne

LT12 Oxidative stress, inflammation and vascular disease in diabetic micro- and macrovascular settings: Evidence for Nrf2-mediated therapeutic strategies

11.25

 

G. Maghzal
Sydney

LT13 Pharmacological inhibition of myeloperoxidase stabilizes atherosclerotic plaques in a mouse model of vulnerable plaque

11.45

 

G. Renshaw
Gold Coast

ST4 Mitochondrial plasticity as a determinant of surviving climate change

12.00-13.00

Lunch Break + AGM of SFRR(A)

13.00-15.00

M. Vissers
M. Simmonds

Session 6: Myopathies/miscellaneous

13.00

 

E. Ledgerwood
Dunedin

PT3 Investigating the mechanism and physiological relevance

of cytochrome c-catalysed cardiolipin oxidation

13.30

 

R. Ritchie
Melbourne

LT14 Novel physiological and pharmacological interventions for targeting diabetes-induced ROS and oxidative stress in the heart

13.50

 

M. Keske
Hobart

LT15 Skeletal muscle microvascular insulin resistance: Role of inflammation and reactive oxygen species

14.10

 

J. Peart
Gold Coast

LT16 Opioid-mediated sustained ligand-activated preconditioning induces cardiac protection in type II diabetes mellitus

14.40

 

J. Russell
Gold Coast

ST5 Type II diabetes impairment of cardiac and mitochondrial stress-resistance: effects of the fission inhibitor MDIVI-1

14.45

 

A. Hickey
Auckland

ST6 Hymenoptera flight muscle mitochondrial function: With great power comes greater oxidative stress

15.00-15.30

Coffee Break

15.30-17.05

K. Truscott
J. Rohlena

Session 7: Radical Chemistry and Biology

15.30

 

Y. Yamamoto
Tokyo

LT17 Detection of hydrogen peroxide in the epidermis of patients with segmental vitiligo

15.50

 

M. Davies
Copenhagen

LT18 Peroxynitrous acid is a potent modifying agent of tropoelastin and gives rise to structural and functional changes

16.10

 

C. Hawkins
Sydney

LT19 Role of the myeloperoxidase oxidant hypothiocyanous acid in the adaption of cells to oxidative stress during inflammation

16.30

 

R. Anderson
Auckland

LT20 Fast chemical repair of DNA radicals by nitroxide antioxidants

16.50

 

K. Fairfull-Smith
Brisbane

ST7 Nitroxide-containing agents for biofilm remediation

 

Free night

 


 

Wednesday, December 7, 2016

Time

Chair

Presenter

Title

9.00-10.25

E. Ledgerwood
K.-H. Wagner

Session 8: Neurodegenerative Diseases I

9.00

 

D. Richardson
Sydney

PT4 Frataxin deficiency in the heart and impaired Nrf2 response

9.30

 

G. Mellick
Brisbane

LT21 Nrf2 and Parkinson's disease

9.50

 

N. Barnett
Brisbane

LT22 A reversible fluorescent probe for the real-time assessment of retinal oxidative status in vivo

10.10

 

D. Pountney
Gold Coast

ST8 Interactions between calcium and oxidative stress in Parkinson's disease

10.25-10.55

Coffee Break

10.55-12.25

M. Keske
G. Mellick

Session 9: Neurodegenerative Diseases II/miscellaneous

10.55

 

S. Wood
Brisbane

LT23 Using the rotenone susceptibility phenotype of idiopathic Parkinson's disease patient cells as a screening platform

11.15

 

M. Hampton
Christchurch

LT24 Redox-relay between peroxiredoxin 2 and collapsin response mediator protein 2

11.35

 

D. Frazer
Brisbane

LT25 The mechanism and regulation of intestinal iron absorption

during early postnatal life

11.55

 

E. Gneiger

Innsbruck

LT26 Facts and artefacts in measurements of H2O2 production under hypoxia

12.10

 

A. Collins
Oslo

ST9 Oxidative damage to DNA measured with the comet assay: From nanoparticles to humans

12.25-13.20

Lunch Break

13.20-14.45

A. Filipovska
A. Perkins

Session 10: Mitochondrial Pathologies I

13.20

 

W. Koopman
Nijmegen

PT5 Mitochondrial dynamics and redox metabolism in mitochondrial (dys)function

13.50

 

K. Truscott
Melbourne

LT27 The role of accessory proteins in the assembly of respiratory complex II

14.10

 

J. Rohlena
Prague

LT28 Electron transport chain-derived ROS in cell death: Mitochondrial complex II and beyond

14.30

 

A. Bezawork-Geleta
Gold Coast

ST10 A crosstalk of mitochondrial respiration and TCA cycle in breast cancer and its effect on tumour formation

14.45-15.15

Coffee Break

15.15-16.30

C. Hawkins
G. Maghzal

Session 11: Mitochondrial Pathologies II

15.15

 

M. Berridge
Wellington

LT29 Intercellular mitochondrial transfer in the brain: a teaser from astrocyte-neuron co-cultures and transfer in a brain tumour model

15.35

 

A. Filipovska
Perth

LT30 Mitochondrial gene regulation in health and disease

15.55

 

A. Perkins
Gold Coast

LT31 Mitochondrial contribution to pathologies of pregnancy

16.15

 

O. Holland
Gold Coast

ST11 Adaptation of placental mitochondria

16.30-17.30

Keynote Talk
R. Stocker

Mike Murphy
Cambridge

KT2 Mitochondrial superoxide production in health and disease

18.30-late

Conference Dinner plus Awards

(Southport Yacht Club)

 


 

Posters, Monday, December 7, 2016, 18.00-20.00

Poster #

Presenter

Title

P1

M. Bhatia
Brisbane

Targeting the thioredoxin system using auranofin in cancer cellsgrown under intermittent hypoxia and as 3D spheroids

P2

E. Clapper
Brisbane

Effect of a ruthenium based compound on thioredoxin reductase and multiple myeloma

P3

Y. Lu
Brisbane

The thioredoxin and DJ-1 antioxidant systems in lymphoma cells

P4

J. Sze
Brisbane

Gold(I) compound, [Au(d2pype)2]Cl as an effective drug to treat multiple myeloma

P5

K. Vick
Christchurch

Expression and redox state of cytosolic and mitochondrial peroxiredoxins in the NCI-60 panel

P6

A. Ayer
Sydney

What regulates the cellular content of the redox-active lipid coenzyme Q?

P7

S. Du Preez
Gold Coast

Bilirubin inhibits hypothiocyanous-acid induced LDL oxidation: A possible contributor to cardiovascular disease protection in smokers

P8

J. Marshall
Dunedin

Biophysical studies of human peroxiredoxin 1 and its oligomeric state transition

P9

L. Hall
Sydney

Oral treatment of high fat diet fed ApoE-/- mice with thiocyanate has varying dose-dependent effects on atherosclerosis development

P10

M. Hicks
Sydney

Clinical experience with pharmacological conditioning of donor hearts with glyceryl trinitrate (GTN) and erythropoietin (EPO) after declaration of circulatory death (DCD)

P11

S. Chiang
Sydney

The effect of N-acetyl cysteine and sulforaphan in modulating the anti-oxidative Nrf2-ARE signalling pathway as potential treatments for Friedreich's ataxia

P12

B. Chami
Sydney

MPO-inhibiting cyclic nitroxides attenuate murine experimental colitis

P13

D. Fazakerley
Sydney

An integrated omics analysis reveals the loss of mitochondrial coenzyme Q10 as a key driver of insulin resistance in adipocytes

P14

D. Cheng
Sydney

Inhibition of myeloperoxidase attenuates endothelial dysfunction during vascular inflammation and atherosclerosis

P15

T. Chien
Sydney

Coenzyme Q10 ameliorates cisplatin-induced nephrotoxicity through rebalancing redox metabolism

P16

C. Hedges
Melbourne

Physiological acidosis alters ROS production and may enhance ROS disposal through the glutathione pathway in skeletal muscle

P17

A. McNamee
Gold Coast

Oxidative stress increases erythrocyte susceptibility to mechanical damage

P18

L. Carroll
Sydney

Formation and detection of tryptophan crosslinks in model compounds, peptides and proteins

P19

L. Carroll
Sydney

Chloramine transfer from imidazole rings to neighbouring amines and the formation of dichloramines

P20

G. Degendorfer
Sydney

Singlet oxygen mediated damage to tryptophan residues: Probing the effect of localised Lys residues on Trp reactivity using model peptides

P21

M. Hampton Christchurch

Peroxiredoxins as markers of oxidative stress in circulating blood cells

P22

M. Jones Christchurch

Importance of timing: The link between reactive oxygen species and the formation of neutrophil extracellular traps

P23

W. Loke Singapore

Plant sterol-enriched soy milk consumption alleviates 5-lipoxygenase and myeloperoxidase reactivities in healthy individuals

P24

J. Devaux Auckland

Adaptive mitochondrial plasticity as a strategy to avoid anoxic succinate accumulation and excess ROS production over reoxygenation in brain of anoxia-tolerant species

P25

G. Ferguson Sydney

Profiling the thiol levels of the de novo glutathione synthesis pathway over the lifespan of Caenorhabditis elegans

P26

F. Radenkovic Gold Coast

Selenium supplementation restores function in placental cells subjected to oxidative stress